A new germline mutation in BRCA1 gene in a sicilian family with ovarian cancer
SummaryA group of 103 sicilian patients with hereditary and familiar breast and/or ovarian cancer were screened for Breast Cancer 1 gene (BRCA1) mutations by direct sequencing PCR products spanning the...
View ArticleBRCA1 genetic testing in 106 breast and ovarian cancer families from southern...
AbstractPurposeTo evaluate the contribution of germline BRCA1 mutations in the incidence of hereditary and familial Breast Cancer (BC) and/or Ovarian Cancer (OC) in patients from Southern Italy (in the...
View ArticleThe Genetics of Breast Cancer
SummaryBreast cancer (BC) is a complex and heterogeneous disease caused by interaction of both genetic and nongenetic risk factors. The biological diversity of sporadic BCs consists in the development...
View ArticleIs BRCA1 -5083del19, identified in breast cancer patients of Sicilian origin,...
AbstractVarious studies have been published in Italy regarding the different BRCA1 mutations, but only the BRCA1-5083del19 mutation is recurrent and specific to individuals of Italian descent with a...
View ArticleHIF-1 is involved in the negative regulation of AURKA expression in breast...
AbstractNumerous microarray-based gene expression studies performed on several types of solid tumors revealed significant changes in key genes involved in progression and regulation of the cell cycle,...
View ArticleBiomarkers as Prognostic, Predictive, and Surrogate Endpoints
AbstractThe improved understanding of tumor biology associated with the recent technological advancement has revealed a growing number of potential tumor biomarkers as candidate for clinical use,...
View ArticleOncogene Addiction in Solid Tumors
AbstractThe term “oncogenic addiction” refers to the phenomenon by which tumor cells become completely dependent on a single pathway, derived from the activation of a specific oncogene, for their...
View ArticleA headlight on liquid biopsies: a challenging tool for breast cancer management
AbstractBreast cancer is the most frequent carcinoma and second most common cause of cancer-related mortality in postmenopausal women. The acquisition of somatic mutations represents the main mechanism...
View ArticleDietary restriction: could it be considered as speed bump on tumor...
AbstractDietary restrictions, including fasting (or long-term starvation), calorie restriction (CR), and short-term starvation (STS), are considered a strong rationale that may protect against various...
View ArticleInvolvement of Non-coding RNAs in Chemo- and Radioresistance of Colorectal...
AbstractDespite recent progress in understanding the cancer signaling pathways and in developing new therapeutic strategies, however, the resistance of colorectal cancer (CRC) cells to chemo- and...
View ArticleNon-coding RNAs Functioning in Colorectal Cancer Stem Cells
AbstractIn recent years, the hypothesis of the presence of tumor-initiating cancer stem cells (CSCs) has received a considerable support. This model suggested the existence of CSCs which, thanks to...
View ArticleTechnical Aspects for the Evaluation of Circulating Tumor Cells (CTCs)
AbstractLiquid biopsy is considered a valid strategy to improve patients’ selection and treatment monitoring in clinical practice. Indeed Circulating Tumor Cells (CTCs) represent an important component...
View ArticleCircular RNA in Exosomes
AbstractCircular RNAs (circRNAs) are a novel family of non-coding endogenous RNAs discovered in all eukaryotic cells and generated through a particular mechanism of alternative splicing called...
View ArticleCardiovascular Damage in Clinical Trials
AbstractThe Cardio-oncology field has grown considerably in the last two decades. The remarkable increase in the number of molecules used in oncology has brought with it a huge set of cardiovascular...
View ArticleOne shot NEPA plus dexamethasone to prevent multiple-day chemotherapy in...
AbstractPurposeChemotherapy-induced nausea and vomiting (CINV) is one of the most feared and disturbing adverse events of cancer treatment associated with decreased adherence to effective chemotherapy...
View ArticleCorrection to: One shot NEPA plus dexamethasone to prevent...
The title of the original paper is incorrect and is now corrected in this aticle.
View ArticleProgrammed Death Ligand 1 (PD-L1) as a Predictive Biomarker for Pembrolizumab...
AbstractRecently, immunotherapy has been shown to be an effective and helpful therapeutic option for the treatment of advanced non-small-cell lung cancer (NSCLC). The activity of antitumor T cells may...
View ArticleValidation of the AJCC prognostic stage for HER2-positive breast cancer in...
AbstractBackgroundThe 8th edition of the American Joint Committee on Cancer (AJCC) staging has introduced prognostic stage based on anatomic stage combined with biologic factors. We aimed to validate...
View ArticleBreast Cancer in Men: Oncology
AbstractBreast cancer in men (BCiM) is a very rare disease that is still understudied and most of the published data comes from small cohorts of patients, compared to breast cancer in women. Genetic...
View ArticleThe diagnostic accuracy of circulating tumor DNA for the detection of...
AbstractThis pooled analysis aims at evaluating the diagnostic accuracy of circulating tumor (ct) DNA for the detection of EGFR-T790M mutation in NSCLC patients who progressed after EGFR-TKIs. Data...
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